Genome dominance is a phenomenon frequently observed in newly developed interspecific hybrids. After merging two diverse genomes in a single nucleus opens, one of the parental genomes becomes dominant, while the other turns to be submissive. In Allium hybrids (A. cepa x A. roylei), we observed that chromosomes of A. cepa are gradually substituted by those of A. roylei. Our study describes that this phenomenon is probably underlined by female meiotic drive. This drive seems to be chromosome-specific; some chromosomes tends to be replaced more frequently than others. Our results contribute to the understanding of the evolutionary mechanisms of hybrid genomes.