We analyzed the meiotic behavior of misdivision products of meiosis: isochromosomes and telocentrics in wheat. The 2 most frequent scenarios were separation of sister chromatids in anaphase I or monopolar/bipolar attachment of the univalent to the spindle apparatus with unseparated chromatids. Misdivision was rare, and its frequency appeared directly related to the size of the centromere. Pairing of identical arms in isochromosomes did not protect them from misdivision. It is not chiasmate pairing that protects from misdivision but mechanistic issues that arise through that pairing. Interestingly, we observed cases of fusion of broken centromeres, all in MII, creating new centric wheat-rye translocations.